Immunosuppressive triterpenes from Tetraena mongolica.
- Author:
Linlin DING
1
;
Qiang LIU
;
Jiaxu HU
;
Shengan TANG
;
Hongquan DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cells, Cultured; Immunosuppressive Agents; chemistry; isolation & purification; pharmacology; Lymphocyte Activation; drug effects; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Triterpenes; chemistry; isolation & purification; pharmacology; Zygophyllaceae; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(3):323-326
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the immunosuppressive constituents from Tetraena mongolica.
METHODChemical constituents were isolated and purified by repeated column chromatography( silica gel, Toyopearl HW40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The MTT assay was applied to evaluate the isolated compounds on the inhibition effect of lymphocyte transformation.
RESULTSix triterpenes were isolated and their structures were identified as follows: 3beta-hydroxy-11alpha, 12alpha:13beta,28-diepoxyoleanane(1), 3beta-(3, 4-dihydroxycinnamoyl)-erythrodi-ol(2), olean-28-al-3beta-yl-caffeate(3), erythrodiol (4), 12-oleanaen-3beta-caffeate(5), 3-O-(E) -coumaroylerythrodiol(6). Compound 24 exhibited the inhibition effects on lymphocyte transformation.
CONCLUSIONCompounds 1-6 were isolated from this plant for the first time, and compound 1 was a new nature product. Compound 2-4 showed significant immunosuppressive activity.
