Optimization of Glycyrrhiza flavonoid and ferulic acid cream by reflect-line orthogonal simplex method.
- Author:
Sheng LIU
1
;
Jun XIE
;
Xiangqing CHEN
;
Liqiang YANG
;
Dan SU
;
Yan FANG
;
Na YU
;
Wei FANG
Author Information
- Publication Type:Journal Article
- MeSH: Coumaric Acids; chemistry; Dosage Forms; Drug Compounding; Drug Stability; Drugs, Chinese Herbal; chemistry; Flavonoids; chemistry; Glycyrrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(4):449-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.
METHODReflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone, based on the appearance, spreadability and stability of the cream.
RESULT9.0% Myrj52-glyceryl monostearate (3:2) and 2.5% dimethicone were chosen in prescription. The prepared cream presented a good stability after being placed 24 h at 5 degrees C, 25 degrees C and 37 degrees C respectively,and its spreadability suited with the property of semi-fluid cream.
CONCLUSION[corrected] The formula of Glycyrrhiza flavonoid and ferulic acid cream is suitable, and its quality is stable. The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.
