Mechanism of Chinese herbal medicine delaying glomerulosclerosis in diabetic nephropathy.
- Author:
Jing CHEN
1
;
Yigang WAN
;
Rongwen BIAN
;
Liubao GU
;
Chaojun WANG
;
Huilan ZHANG
;
Jian YAO
Author Information
1. Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, China. ada47@sohu.com
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetic Nephropathies;
drug therapy;
immunology;
metabolism;
prevention & control;
Drugs, Chinese Herbal;
therapeutic use;
Glomerulonephritis;
drug therapy;
immunology;
metabolism;
prevention & control;
Humans;
Oxidative Stress;
drug effects
- From:
China Journal of Chinese Materia Medica
2010;35(4):525-530
- CountryChina
- Language:Chinese
-
Abstract:
The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine.
