The effect of substance P on functional proteins in human neutrophil.

Author: Lin YANG ¹ ; Xiang-guang FA
Author Information

1. Department of Biochemistry, Institute of Hematology, CAMS, PUMC, Tianjin 300020, China.
Publication Type:Journal Article
MeSH: Acid Phosphatase; metabolism; Humans; Membrane Proteins; physiology; Neutrophils; metabolism; Respiratory Burst; Substance P; pharmacology
From: Acta Academiae Medicinae Sinicae 2002;24(1):98-101
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the effect of substance P (SP) on the functional proteins on plasma membrane of neutrophil (Np).
METHODThe response of Np to SP was examined by measuring the level of respiratory burst, the activities of ACP and ALP, the fluoroscopy intensity of CR3, CD45 and FM-LP.
RESULTSIt was found that SP could increase respiratory burst of Np, decrease the activity of acid phosphatase (ACP), but had no effect on alkaline phosphatase (ALP). SP could also promote the amount of CD45, complement receptor type 3 (CR3) and N-Formyl-Met-Leu-Phe (FMLP) receptors.
CONCLUSIONThe results showed that the effects of SP on functional proteins in human Np membrane were universality and diversity. It implied that SP could affect various inflammation responses in Np.