Progress in the studies on the relationship between the polymorphism of P22phox gene and coronary heart disease.
- Author:
Jian-gong ZHAO
1
;
Dong-feng GU
Author Information
1. Division of Population Genetics & Prevention, Fuwai Cardiovascular Institute, CAMS, PUMC, Beijing 100037, China.
- Publication Type:Journal Article
- MeSH:
Coronary Disease;
genetics;
Genetic Markers;
Humans;
Membrane Transport Proteins;
genetics;
NADPH Dehydrogenase;
genetics;
NADPH Oxidases;
Phosphoproteins;
genetics;
Polymorphism, Genetic;
Risk Factors
- From:
Acta Academiae Medicinae Sinicae
2002;24(1):105-104
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species (ROS) are thought to contribute to the progression of cardiovascular disease (CVD). At present, it has been known that the NADH/NADPH oxidase system is the major source of superoxide in the vascular system. Cytochrome b-245 (P22phox), which is a critical component of NADH/NADPH oxidase, plays an important role in electron transport and producing the superoxide anion. It is considerable to take attention to whether the polymorphism of P22phox gene is associated with a risk of coronary heart disease (CHD). To distinguish the relationship between them will be beneficial to elucidate the genetic mechanisms of CHD, and develop a new genetic marker to provide theoretical base for the prevention and cure of CHD.
