Expression of nuclear factor-kappaB in traumatic cataract.
- Author:
Qian YANG
1
;
Gui-Qiu ZHAO
;
Qian LI
;
Xiang-Ping LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Cataract; genetics; metabolism; therapy; Epithelial Cells; metabolism; Female; Humans; Lens, Crystalline; injuries; metabolism; Male; NF-kappa B; genetics; metabolism; Polymerase Chain Reaction
- From: Chinese Journal of Traumatology 2006;9(2):86-90
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the differences in expression of nuclear factor-kappaB (NF-kappaB) between human traumatic cataract and normal lenticular epithelial cells.
METHODSTotal RNA of anterior capsule specimens was taken under the microscope from normal cadaveric eyes donors and those suffering from traumatic cataract to make semi-quantitative RT-PCR and conduct analysis of differences in expression of NF-kappaB between them.
RESULTSAs compared with the mean of 0.8337 in normal control group, the expression equivalent of NF-kappaB was 0.9074 for the lenticular epithelial cells in traumatic cataract sufferers, and the differences are of noticeable significance (t = 2.447, P<0.05) accordingly.
CONCLUSIONSNF-kappaB is likely a kind of transcription factor necessary to maintain metabolism of normal lenticular epithelial cells. Higher NF-kappaB available in the traumatic cataract sufferer's lenticular epithelial cells means NF-kappaB is of possible relevance to occurrence and development of traumatic cataract.
