Delayed release particles from vascular endothelial growth factor for repairing spinal cord ischemic injury of rats.
- Author:
Yang CHEN
1
;
Feng LI
;
Jian-de XIAO
;
Zhen-yu LI
;
Lei YANG
;
Xin-le LUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Delayed-Action Preparations; Microcirculation; drug effects; Models, Animal; Neovascularization, Physiologic; drug effects; Rats; Rats, Wistar; Spinal Cord Injuries; rehabilitation; therapy; Spinal Cord Ischemia; therapy; Vascular Endothelial Growth Factors; administration & dosage; therapeutic use
- From: Chinese Journal of Traumatology 2007;10(1):49-52
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effect of delayed release particles from vascular endothelial growth factor (VEGF) on the reparation of ischemic injury of spinal cord in rats.
METHODSThe spinal cord ischemia model of rats was established. The delayed release particles from VEGF were injected via the intubation of spinal subarachnoid space. The rehabilitation was observed by the assessment of unfold claw reflection, space between toes, spinal evoked potential (SEP) and motor evoked potential (MEP).
RESULTSVEGF prompted SEP and MEP appearance, improved the motor function of hind limbs.
CONCLUSIONSVEGF can promote the rehabilitation of spinal cord ischemic injury of rats.
