Effect of the Baseline Vitamin D Level on Growth Outcome in Pediatric Crohn Disease.
10.5223/pghn.2017.20.1.41
- Author:
Eun Joo LEE
1
;
Jin Soo MOON
;
Jae Sung KO
;
Hye Ran YANG
;
Ju Young JANG
;
Ju Whi KIM
;
Kyung Jae LEE
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. mjschj@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Pediatric Crohn's disease;
Vitamin D;
Growth
- MeSH:
Body Mass Index;
Child;
Crohn Disease*;
Follow-Up Studies;
Humans;
Prevalence;
Retrospective Studies;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2017;20(1):41-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Vitamin D deficiency is common in Crohn disease (CD). The aim of the study was to examine the prevalence of vitamin D deficiency and evaluate the association between vitamin D status and growth outcome in Korean pediatric CD patients. METHODS: In this retrospective study, 17 children younger than 18 years old diagnosed with CD were enrolled and their serum 25-hydroxy vitamin D (25[OH]D) was checked between 2011 and 2015. We categorized the patients into two groups, Group 1 and Group 2. Group 1 included patients with serum 25(OH)D levels below 10 ng/mL, and Group 2 was for patients with a 25(OH)D serum levels between 10 ng/mL and 30 ng/mL. The z-scores for height (Htz), weight (Wtz), and body mass index (BMIz) were measured at baseline, 6 months, and 12 months. RESULTS: The mean serum 25(OH)D levels of the total 65 CD patients and 17 enrolled patients were 15.64±6.9 ng/mL and 13.1±5.1 ng/mL, respectively. There was no correlation at the beginning of the study between vitamin D level and growth parameters (Htz, Wtz, BMIz) or other variables including laboratory data and Pediatric Crohn Disease Activity Index. The Htz, Wtz, and BMIz in Group 1 showed no significant improvement at 6 months and 12 months follow-up. In Group 2, Wtz and BMIz showed significant improvements sustained until 12 months of follow-up. Htz showed no significant improvement at 6 months but there was significant improvement at 12 months. CONCLUSION: It seems that baseline vitamin D status affects growth outcome in pediatric CD.
