Neurological complications following haploidentical bone marrow transplantation.
- Author:
Heng-Xiang WANG
1
;
Shu-Quan JI
;
Ling ZHU
;
Jing LIU
;
Mei XUE
;
Li DING
;
Lian-Ning DUAN
;
Hong-Min YAN
;
Hui-Ren CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Bone Marrow Transplantation; adverse effects; immunology; Child; Female; Histocompatibility; Humans; Intracranial Hemorrhages; etiology; Leukemia; surgery; Male; Nervous System Diseases; etiology
- From: Journal of Experimental Hematology 2005;13(6):1128-1130
- CountryChina
- Language:Chinese
-
Abstract:
UNLABELLEDTo explore the occurrence patterns of neurological complications following haploidentical bone marrow transplantation, a series of clinical data as the onset time, etiology, choices of therapies and prognosis in 10 patients with neurological disorders were summarized. The results showed that complications occurred in 10 out of 74 patients after bone marrow transplantation, which include 3 with encephalorrhagia, 3 infection, 1 epilepsy, 1 Guillian-Barr's syndrome, 1 encephalopathy and 1 schizophrenia. 4 patients died of neurological complications.
IN CONCLUSIONneurological complications commonly occurred in haploidentical bone marrow transplantation, and encephalorrhagia might be the main indication that needs intensive care. Moreover, central nerve system infection and peripheral nerve diseases associated with slow immune reconstitution should have clinical interests.