Mechanism of CD4+CD25+ and CD8+ regulatory T cells--review.
- Author:
Yuan OU
1
;
Ping ZHU
Author Information
1. Department of Hematology, The First Hospital of Peking University, Beijing 10034, China.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
immunology;
prevention & control;
CD8-Positive T-Lymphocytes;
immunology;
Graft vs Host Disease;
immunology;
prevention & control;
Humans;
Interleukin-2 Receptor alpha Subunit;
immunology;
T-Lymphocytes, Regulatory;
immunology
- From:
Journal of Experimental Hematology
2005;13(6):1137-1140
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can inhibit inappropriate self-reactive T cells, as well as limit the range, extent and lasting time of immune responses, so as to inhibit the proliferation of CD4(+) and CD8(+) effector T cells. In view of these properties, there is little doubt about the enormous potential value of Tregs in molecular mechanisms and clinical treatment of human autoimmune disorders, graft-versus-host disease (GVHD) and allergies. In this review, the molecular mechanisms of CD4(+)CD25(+) Treg and CD8(+) Treg were mainly discussed, and challenge with which study on Treg cells is faced and prospects were briefly described.
