Immunophenotypic features in leukemia of NK cell series.
- Author:
Rou MA
1
;
Yong-Gang XU
;
Xiao-Hong YANG
;
Xiao-Mei HU
;
Liu LI
;
Xu-Dong TANG
;
Shan-Shan ZHANG
;
Shu XU
;
Hong-Zhi WANG
;
Feng LIU
Author Information
1. Xiyuan Hospital, China Academy of TCM, Beijing 100091, China. xyxysys@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
CD56 Antigen;
metabolism;
Female;
Humans;
Immunophenotyping;
Killer Cells, Natural;
immunology;
Leukemia, Myeloid, Acute;
immunology;
Lymphoma, T-Cell;
immunology;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
immunology
- From:
Journal of Experimental Hematology
2006;14(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
The aim was to investigate the immunophenotypes of NK series leukemia. Immunophenotypes of 297 cases of acute leukemia (AL) were measured by flow cytometry, and these immucopenotypic features were analyzed. The results showed that 43 out of 297 cases of AL (14.5%) were CD56 positive. 6 cases were NK series leukemia and 37 cases were acute myelogenous leukemia with CD56 expressed. One patient has been diagnosed as myeloid/NK cell precursor acute leukemia, two patients were blastic NK cell leukemia, one was supposed to be NK-like T-cell lymphoma/leukemia, while another one was large granular lymphocyte leukemia (LGLL). It is concluded that almost all of CD56 positive leukemia were acute myelogenous leukemia with CD56 expressed. The immunophenotypes of NK series leukemia were antigens from hematopoietic stem cells to T/NK progenitor cells with meyloid antigen positive, and through NK progenitors to mature NK cells. The immunophenotypes of heterogeneous NK leukemia cells are different, that should be carefully distinguished.
