Immunologic classification used in typing of 68 cases of acute leukemias.
- Author:
Xiu-Li SUN
1
;
Mei-Yun FANG
;
Feng JIANG
;
Yuan JING
Author Information
1. Department of Hematology, The First-Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Antigens, CD;
biosynthesis;
Antigens, CD34;
biosynthesis;
Antigens, CD7;
biosynthesis;
Antigens, Differentiation, Myelomonocytic;
biosynthesis;
CD13 Antigens;
biosynthesis;
Female;
Humans;
Immunophenotyping;
Leukemia, Myeloid, Acute;
classification;
immunology;
Lipopolysaccharide Receptors;
biosynthesis;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
classification;
immunology;
Sialic Acid Binding Ig-like Lectin 3
- From:
Journal of Experimental Hematology
2006;14(1):39-41
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the significance of immunologic classification for typing of acute leukemia (AL). 68 cases of AL were classified by morphologic and immunologic typings. The results showed that the consistency rate was 94.1% between morphology and immunology, and 4 morphologic misdiagnosed cases were corrected by immunology; CD13 and CD33 were special myeloid lineage-associated antigens; AML-M(3) was often CD34 low-expressed and HLA-DR-negative; CD14 was often expressed in AML-M(4) and M(5); lymphoid lineage-associated antigens (CD7) were easily found in ANLL, and myeloid lineage-associated antigens were also found in ALL. In conclusion, immunologic classification can improve the accuracy in acute leukemia diagnosis. The diagnosis of some special AL, such as acute unidentified leukemia (AUL), AML-M(0) and so on, must rely on immunologic classification.
