Unrelated donor peripheral blood stem cell transplantation for hematologic malignancies.
- Author:
Chun-Ji GAO
1
;
Wan-Ming DA
;
Bo-Long ZHANG
;
Xiao-Ping HAN
;
Yu JING
;
Hong-Hua LI
;
Jian BO
;
Hai-Yan ZHU
;
Hai-Jie JIN
;
Xiao-Xiong WU
;
Quan-Xun WANG
;
Su-Sia LI
;
Wen-Rong HUANG
;
Li YU
Author Information
1. Department of Hematology, General Hospital of China PLA, Beijing 100853, China. gaochunji@hotmail.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Blood Donors;
Female;
Graft vs Host Disease;
prevention & control;
Humans;
Male;
Peripheral Blood Stem Cell Transplantation;
methods;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
therapy
- From:
Journal of Experimental Hematology
2006;14(1):112-115
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore feasibility and efficacy of unrelated donor peripheral blood stem cell transplantation (UD-PBSCT) in treatment of hematologic malignancies. Ten patients with hematologic malignancies underwent high resolution DNA based typing HLA-matched or 1 locus mismatched UD-PBSCT. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preconditioning regimen in all cases. All patients received mycophenolate mofetile, cyclosporin A and short-term methotrexate with CD25 antibody as the graft-versus-host disease (GVHD) prophylaxis. The results showed that rapid engraftment was observed in all cases who presented full donor chimerism at 28 days post transplantation by STR-PCR. The median time of neutrophil recovery > 0.5 x 10(9)/L, platelet recovery > 20 x 10(9)/L was 13, 17.5 days respectively after transplantation. The incidence of acute GVHD was 3 cases (one case with grade I was recovered from GVHD by himself, one case with grade III was cured, one case with grade VI was died). It is concluded that above-mentioned preconditioning regimen and GVHD prophylaxis are effective approaches for unrelated donor peripheral blood stem cell transplantation in hematopoietic malignancies.
