Identification of the isoform in type II receptor of transforming growth factor-beta in patients with acute leukemia and its clinical significance.
- Author:
Ping CHEN
1
;
Yuan-Zhong CHEN
;
Yong WU
;
Hui-Fang HUANG
;
Nai-Nong LI
Author Information
1. Department of Hematology, Affiliated Union Hospital, Fujian Medical University, Fuzhou 350004, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Base Sequence;
Female;
Humans;
Leukemia, Myeloid, Acute;
metabolism;
Male;
Middle Aged;
Molecular Sequence Data;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
metabolism;
Prognosis;
Protein Isoforms;
Protein-Serine-Threonine Kinases;
classification;
metabolism;
Receptors, Transforming Growth Factor beta;
classification;
metabolism;
Signal Transduction;
Transforming Growth Factor beta;
metabolism
- From:
Journal of Experimental Hematology
2006;14(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Recent research indicates that TGF-beta and type II receptor (TbetaR-II) play an important role in the pathogenesis of tumor. A high frequency of abnormalities in TbetaR-II has been demonstrated in various cancers. To identify the mutation of TbetaR-II in patients with acute leukemia, the bone marrow samples from 6 patients with acute leukemia and 11 normal individuals as control were detected by long-range RT-PCR. To detect a deletion in sequence of the TbetaR-IIgene, the PCR products were cloned to T vector and then sequenced. The results showed that there was existance of the isoform of TbetaR-II in 2 cases out of 6 patients with acute leukemia. These two patients had more poor prognosis than others. In conclusion, there was the isoform of TbetaR-II in partial patients with acute leukemia, and the isoform may be related with prognosis.
