Effect of 5-hydroxtryptamine on megakaryocytopoiesis--review.
- Author:
Yuan-Shan CHENG
1
;
Yuan-Sheng LIU
;
Mo YANG
Author Information
1. Department of Hematology, The First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Megakaryocytes;
physiology;
Receptors, Serotonin;
metabolism;
Receptors, Serotonin, 5-HT2;
metabolism;
Serotonin;
metabolism;
pharmacology;
Thrombopoiesis;
physiology;
Thrombopoietin;
physiology
- From:
Journal of Experimental Hematology
2006;14(2):403-407
- CountryChina
- Language:Chinese
-
Abstract:
5-hydroxtryptamine (5-HT, serotonin) has been recognized not only as a neurotransmitter and vasoactive agent, but also as a growth factor. 5-HT mainly binds to 5-HT(2) receptors or 5-HT(1) receptors on cell surface to stimulate cell proliferation through Ras or MAPK pathway in many cell types. It has been reported that 5-HT stimulates megakaryocytopoiesis via 5-HT receptors. The possible mechanism of 5-HT on the proliferation and differentiation of megakaryocytes (MK) has been discussed in this review article. In early stage of megakaryocytopoiesis, 5-HT may bind to 5-HT(2B) receptor on megakaryocytes, and promotes their proliferation and differentiation. In the late stage, 5-HT may involve in the platelet release procedure by inducing nitric oxide (NO) synthesis via 5-HT(2A) receptors. 5-HT can also antagonize the apoptotic effect induced by thrombospondin-1 (TSP-1) which is a platelet alpha granule protein and has synergic effect with platelet-derived growth factor (PDGF) to enhance megakaryocytes proliferation. Therefore, 5-HT is likely to be an important substance in the feedback regulation of thrombopoiesis. In this review the 5-HT and its receptors, 5-HT as cell growth factor, pathway of 5-HT stimulating cell proliferation and influance of 5-HT on MK-progenitor cells were summarized.
