CD4+CD25+ regulatory T cells and their function in graft-versus-host disease--review.
- Author:
Bei YAN
1
;
Wan-Ming DA
Author Information
1. Department of Hemotology, The General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
CD4 Antigens;
analysis;
Graft vs Host Disease;
etiology;
immunology;
Humans;
Interleukin-2 Receptor alpha Subunit;
analysis;
T-Lymphocytes, Regulatory;
cytology;
immunology;
metabolism
- From:
Journal of Experimental Hematology
2006;14(2):408-412
- CountryChina
- Language:Chinese
-
Abstract:
As a functionally and phenotypically distinctive T cell subpopulation, CD4+CD25+ regulatory T cells are anergic and retain their ability to suppress antigen-driven response of CD4+CD25- cells in a contact-dependent manner or through a way of secreting immunosuppressive cytokines such as IL-10 and TGF-beta. Graft-versus-host disease (GVHD) is one of the major complications following allogeneic hematopoietic stem cell transplantation (HSCT). Recently, some researches on the relationship between donor CD4+CD25+ regulatory T cells and GVHD severity produced two contradictory conclusions: one is CD4+CD25+ regulatory T cells that can prevent GVHD efficiently; the other is that GVHD is associated with the increased numbers of peripheral blood CD4+CD25+ regulatory T cells. The answer to this question will provide a new idea for clinic therapy of GVHD. In this review some new research progresses in the related area, such as the CD4+CD25+ regulatory T cells, the phenotype, characteristics, immunoregulatory mechanisms of CD4+CD25+ regulatory T cells, as well as the relation of CD4+CD25+ with GVHD were presented.
