Effect of different duration of clopidogrel pretreatment on platelet activation in patients undergoing stenting.
- Author:
Fang LIU
1
;
Jia-Chun LIU
;
Li-Jun WANG
;
Jin LI
;
Xiao-Dong XU
;
Yan LIU
;
Yi-Ning HUANG
;
Da-Ming WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Aged, 80 and over; Carotid Stenosis; blood; therapy; Female; Humans; Male; Middle Aged; Platelet Activation; drug effects; Platelet Aggregation Inhibitors; administration & dosage; Stents; Ticlopidine; administration & dosage; analogs & derivatives; Time Factors
- From: Chinese Journal of Surgery 2009;47(6):411-414
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of two clopidogrel pretreatment duration on platelet activation in patients undergoing stenting.
METHODSFrom July 2006 to December 2007 40 elective carotid or vertebral artery stenting patients were assigned into two groups: Group A (n = 24) initiated clopidogrel (75 mg/d) > or = 5 d before stenting; group B (n = 16) initiated 3 - 4 days. Platelet-monocyte aggregates and fibrinogen receptors analyzed by flow cytometric, and platelet aggregation tests using optical aggregometry, as well as serum soluble CD40 ligand quantified by enzyme-linked immunosorbent assay were assessed in peripheral blood samples obtained immediately before and at 0.5, 18 h and 6 d after stenting.
RESULTSPlatelet-monocyte aggregates, fibrinogen receptors and serum soluble CD40 ligand were higher in group B than in group A (14.59% vs 8.70%, P = 0.012; 4.87% vs 2.42%, P = 0.024; 5.79 microg/L vs 2.64 microg/L, P = 0.020) at 18 h after stenting. Serum soluble CD40 ligand was higher in group B than in group A (0.49 microg/L vs 0.31 microg/L, P = 0.033) at 0.5 h after stenting.
CONCLUSIONSPremedication before stenting with clopidogrel 75 mg/d merely 3 - 4 d may be insufficient to achieve adequate platelet inhibition, whereas clopidogrel initiated at least 5 d could obtain preferable clinical antiplatelet efficacy.
