Effects of human urinary tissue kallikreins on vasodilation of basilar artery in rabbits with symptomatic cerebral vasospasm.
- Author:
Sheng-Lin PEI
1
;
Yi-Nan MENG
;
Jun-Lu WANG
;
Zhang-Yong HU
;
Yun-Chang MO
;
Le-Ping ZHOU
;
Wei-Jian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Humans; Male; Nimodipine; therapeutic use; Rabbits; Random Allocation; Tissue Kallikreins; therapeutic use; Vasodilator Agents; therapeutic use; Vasospasm, Intracranial; drug therapy
- From: Chinese Journal of Surgery 2009;47(9):697-700
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of urinary kallidinogenase on subarachnoid hemorrhage (SAH) in rabbits.
METHODSRabbits symptomatic cerebral vasospasm model was built though Endo method, among the 40 rabbits, 8 died or had severe nervous system syndrome, the other 32 were randomly divided into 4 groups:group A, control group, injection of normal saline to the cisterna magna;group B, subarachnoid hemorrhage;group C, injection of human urinary tissue kallikreins;group D, treated with Nimodipine. The behavior scores, neurological scores and cerebral angiography changes were observed.
RESULTSFood intake obviously decreased and neurological deficit were seen in group B, while which were attenuated in group C and group D, and group A was normal. Comparing the diameter of basilar artery was (1.9 +/- 0.3) mm before SAH, the diameter of group B 4 d later was (1.5 +/- 0.3) mm, 7 d later (1.4 +/- 0.3) mm, the difference was significant (P < 0.05). Comparing with group C on the day 4th and 7th, the diameters of basilar artery were significantly different (P < 0.001). Comparing with group D on the day 4th, 7th and 14th, there was no obvious improvement.
CONCLUSIONUrinary kallidinogenase and Nimodipine can obviously alleviate symptomatic cerebral vasospasm in rabbits remarkably, but the former's effect of attenuating vasospasm is better than that of Nimodipine.
