The correlation of the fetal cytokeratin expressing in epidermal cells and the different outcomes of wound repairing.
- Author:
Xin-jing WEI
1
;
Du-yin JIANG
;
Xian-lei ZONG
;
Xiao-bing FU
;
Zhi-yong SHENG
;
Wei WANG
;
Fei SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cell Differentiation; Cell Proliferation; Child; Child, Preschool; Cicatrix; metabolism; pathology; Epidermis; metabolism; pathology; Epithelial Cells; metabolism; pathology; Female; Humans; Hyperplasia; metabolism; pathology; Infant; Keratins; metabolism; Male; Middle Aged; Wound Healing; Young Adult
- From: Chinese Journal of Surgery 2009;47(16):1245-1248
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changing regular of specific cytokeratin (CK) markers expressing in human pseudoepitheliomatous hyperplasia (PEH), keloids (Ke) and hypertrophic scar (HS) lesion, and to explore the correlation between such changes and the different outcomes of wound repair.
METHODSHistopathology and immunohistochemistry (IHC) double staining methods were used in samples of human PEH, Ke, HS and NS to determine the distribution characteristics and changing regularity of CKs in epidermal tissues.
RESULTSNo CK8&18 and CK17 expressed in epidermis of NS group, while CK8&18(+) cells and CK17(+) cells were detected in epidermis of active-stage Ke, HS and PEH. The quantities of CK8&18(+) cells and CK17(+) cells ranked as follows: PEH > Ke > HS and HS > Ke > PEH (P < 0.05). CK19(+) cells and CK5&6(+) cells expressed similar changing trend, while reverse trend of CK10(+) cells was detected in epidermal cells, with local epidermal hyperplasia, cells morphological changes and sub-epidermal inflammatory reaction.
CONCLUSIONDifferent degree of de-differentiation and terminal differentiation imbalance are found in epidermal cells of active-stage PEH, Ke and HS, which hint the correlation between the abnormal proliferation and differentiation of epidermal cells and the different outcomes of wound repair.
