The Diagnostic Value of the HCG Stimulation Test for 5 alpha-reductase Deficiency in Children.
- Author:
Seung Kang CHOI
1
;
Jae Woo KIM
Author Information
1. Department of Urology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
HCG stimulation test;
5 alpha-reductase deficiency
- MeSH:
Child*;
Cholestenone 5 alpha-Reductase*;
Dihydrotestosterone;
Female;
Humans;
Hypospadias;
Male;
Testosterone
- From:Korean Journal of Urology
1989;30(6):856-859
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We evaluated 15 children with hypospadias or micropenis for the presence of 5 a-reductase deficiency. Serum testosterone and dihydrotestosterone(DHT) concentrations were measured before and 3 days after HCG stimulation. Also, testosterone : dihydrotestosterone (T:DHT) conversion ratios were calculated in each children in order to determine the activity of 5 a-reductase. DHT was abnormally low in 14 children, and T:DHT conversion ratios were abnormal in 12 children in basal state. But T:DHT conversion ratios were abnormal in 2 children after HCG stimulation. In children, 5 a-reductase deficiency can not be diagnosed low serum DHT or abnormal T:DHT conversion ratio, but diagnosed abnormally high T:DHT conversion ratio after HCG stimulation.
