Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis.
10.3346/jkms.2011.26.9.1132
- Author:
Yeon Sik HONG
1
;
Su Jin MOON
;
Young Bin JOO
;
Chan Hong JEON
;
Mi La CHO
;
Ji Hyeon JU
;
Hye Jwa OH
;
Yu Jung HEO
;
Sung Hwan PARK
;
Ho Youn KIM
;
Jun Ki MIN
Author Information
1. Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea. rmin6403@hanmail.net
- Publication Type:Original Article
- Keywords:
Interleukin-33;
sST2, ST2L;
Arthritis, Rheumatoid
- MeSH:
Adult;
Aged;
Antirheumatic Agents/therapeutic use;
Arthritis, Rheumatoid/blood/drug therapy/*pathology;
C-Reactive Protein/analysis;
Female;
Humans;
Interleukin-1beta/analysis/blood;
Interleukin-6/analysis/blood;
Interleukins/*analysis/blood;
Male;
Middle Aged;
Osteoarthritis/blood/pathology;
Receptors, Cell Surface/*analysis/blood;
Synovial Fluid/metabolism
- From:Journal of Korean Medical Science
2011;26(9):1132-1139
- CountryRepublic of Korea
- Language:English
-
Abstract:
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 +/- 464.0 pg/mL) than in healthy controls (96.0 +/- 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1beta (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naive RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
