Natural Course of Cow's Milk Allergy in Children with Atopic Dermatitis.
10.3346/jkms.2011.26.9.1152
- Author:
Jungmin SUH
1
;
Hyeonyoung LEE
;
Jung Hyun LEE
;
Joongbum CHO
;
Jung Seok YU
;
Jihyun KIM
;
Youngshin HAN
;
Kangmo AHN
;
Sang Il LEE
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Environmental Health Center for Atopic Diseases, Seoul, Korea. kmaped@skku.edu
- Publication Type:Original Article
- Keywords:
Milk;
Food Hypersensitivity;
Immunoglobulin E;
Prognosis
- MeSH:
Animals;
Cattle;
Child;
Child, Preschool;
Dermatitis, Atopic/complications/*diagnosis;
Female;
Follow-Up Studies;
Humans;
Immune Tolerance;
Immunoglobulin E/blood;
Infant;
Male;
Milk/immunology;
Milk Hypersensitivity/complications/*diagnosis;
Odds Ratio;
Prognosis;
Time Factors
- From:Journal of Korean Medical Science
2011;26(9):1152-1158
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cow's milk is one of the most common food allergens in children with atopic dermatitis (AD). This study was conducted to describe the natural course of cow's milk allergy in children with AD, and to identify factors predictive of outcome. To accomplish this, we reviewed the medical records of 115 children who were diagnosed with AD and cow's milk allergy before 24 months of age to evaluate their clinical characteristics and prognostic factors. During a follow-up period of 24 to114 months, the median age for tolerance to cow's milk was found to be 67 months. Multivariate analysis using the Cox proportional hazard model revealed that the peak cow's milk-specific IgE level within 24 months after birth was the most important factor for prediction of the outcome of cow's milk allergy. In conclusion, half of the children younger than 24 months of age with AD and cow's milk allergy could tolerate cow's milk at 67 months of age. The peak cow's milk-specific IgE level within the first 24 months of birth is useful to predict the prognosis of cow's milk allergy in children with AD.
