Non-Dipper Status and Left Ventricular Hypertrophy as Predictors of Incident Chronic Kidney Disease.
10.3346/jkms.2011.26.9.1185
- Author:
Hye Rim AN
1
;
Sungha PARK
;
Tae Hyun YOO
;
Shin Wook KANG
;
Jung Hwa RYU
;
Yong Kyu LEE
;
Mina YU
;
Dong Ryeol RYU
;
Seung Jung KIM
;
Duk Hee KANG
;
Kyu Bok CHOI
Author Information
1. Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea. drryu@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Blood Pressure Monitoring, Ambulatory;
Hypertrophy, Left Ventricular;
Renal Insufficiency, Chronic
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Albumins/analysis;
Blood Pressure;
Blood Pressure Monitoring, Ambulatory;
Cholesterol, HDL/blood;
Chronic Disease;
Creatinine/blood/urine;
Cross-Sectional Studies;
Female;
Follow-Up Studies;
Glomerular Filtration Rate;
Humans;
Hypertension/complications;
Hypertrophy, Left Ventricular/complications/*diagnosis;
Incidence;
Kidney Diseases/epidemiology/*etiology/ultrasonography;
Male;
Middle Aged;
*Predictive Value of Tests;
Retrospective Studies
- From:Journal of Korean Medical Science
2011;26(9):1185-1190
- CountryRepublic of Korea
- Language:English
-
Abstract:
We have hypothesized that non-dipper status and left ventricular hypertrophy (LVH) are associated with the development of chronic kidney disease (CKD) in non-diabetic hypertensive patients. This study included 102 patients with an estimated glomerular filtration rate (eGFR) > or = 60 mL/min/1.73 m2. Ambulatory blood pressure monitoring and echocardiography were performed at the beginning of the study, and the serum creatinine levels were followed. During the average follow-up period of 51 months, CKD developed in 11 patients. There was a significant difference in the incidence of CKD between dippers and non-dippers (5.0% vs 19.0%, P < 0.05). Compared to patients without CKD, patients with incident CKD had a higher urine albumin/creatinine ratio (52.3 +/- 58.6 mg/g vs 17.8 +/- 29.3 mg/g, P < 0.01), non-dipper status (72.7% vs 37.4%, P < 0.05), the presence of LVH (27.3% vs 5.5%, P < 0.05), and a lower serum HDL-cholesterol level (41.7 +/- 8.3 mg/dL vs 50.4 +/- 12.4 mg/dL, P < 0.05). Based on multivariate Cox regression analysis, non-dipper status and the presence of LVH were independent predictors of incident CKD. These findings suggest that non-dipper status and LVH may be the therapeutic targets for preventing the development of CKD in non-diabetic hypertensive patients.
