Synthesis and assay of the antibacterial and antifungal properties of some derivatives of 3-[3,5-dichloro salicylamido] rhodanine:
- Author:
Nga Dinh Nguyen
- Publication Type:Journal Article
- Keywords:
rhodanine
- MeSH:
Rhodanine;
Analogs & derivatives
- From:Pharmaceutical Journal
1999;279(7):12-15
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
3-[3,5-dichloro salicylamido] rhodanine was obtained by method dithiocarbamat. Condensation of 3-[3,5-dichloro salicylamido] rhodanine with p-dimethylaminobenzaldehyd, benzaldehyd, furfural, aldehyd salicylic to get four 5 -aryliden 3-[3,5-dichloro salicylamido] rhodanine. Condensation 3-[3,5-dichloro salicylamido] rhodanine with phenylhydrazin to get 2-phenyl hydrazon 3-[3,5-dichloro salicylamido] rhodanine. All of them were not seen in reference document. The structures of the obtained products were characterized by elemental analysis and IR spectroscopy. The results obtained on the test of antibiotic and antifungal activities showed that most of them had strong effect on tested bacteria Gram(+) and weak effect on bacteria Gram (-) and fungus.
