Recent progress in interferon induced protein GBP1 research.
- Author:
Zi-Xiang ZHU
;
Yang-Chun CAO
;
Wei-Jun CAO
;
Fan YANG
;
Zhi-Yong MA
;
Hai-Xue ZHENG
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
metabolism;
Antiviral Agents;
metabolism;
GTP-Binding Proteins;
chemistry;
genetics;
metabolism;
Humans;
Interferons;
genetics;
metabolism
- From:
Chinese Journal of Virology
2014;30(4):456-462
- CountryChina
- Language:Chinese
-
Abstract:
Guanylate-binding protein 1 (GBP1) is an interferon induced protein, that belongs to the guany late-binding protein family. GBP1 is widely involved in anti-infection immune responses, anti-tumor activity and various biological reactions. Recent studies have proved that IFN-alpha, IFN-beta, IFN-gamma, IL1alpha, IL1beta, TNF-alpha and LPS can induce GBP1 expression; hence, the diverse biological functions of GBP1 have been gradually deduced and exploited. Many studies have been performed over recent years to understand the exact mechanisms that underlie the anti-infection and anti-tumor properties of GBP1. This review describes the molecular structure, biological activity, anti-infective properties and other functions of GBP1, in order to provide insights into the divergent roles of GBP1 in the regulation of various biological processes.
