Current research on picornavirus 3C protease.
- Author:
Hong WANG
1
;
Guang-Cheng XIE
;
Zhao-Jun DUAN
Author Information
1. National Institute for Viral Disease Control and Prevention, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Cysteine Endopeptidases;
physiology;
Immunity, Innate;
Picornaviridae;
enzymology;
immunology;
Viral Proteins;
physiology;
Virus Replication
- From:
Chinese Journal of Virology
2014;30(5):579-586
- CountryChina
- Language:Chinese
-
Abstract:
The picornavirus family comprises many small viruses, several of which are important pathogens of humans and livestock. The 3C protease (3Cpro) of different species and genera of picornavirus contains the classic G-X-C-G motif and Cys-His-Asp/Glu catalytic triad. 3Cpro conducts maturation cleavage in the regions of VP2-VP3 and VP3-VP1 in P1, 2A-2B and 2B-2C in P2 and the whole P3. Picornavirus 3Cpro has been shown to have significant substrate preference in Q-G/S/A/V/H/R and E-S/G/R/M as well as species and genera specificity through analyses of the maturation cleavage of picornavirus polyproteins. Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites). Useful information will be provided for the development of broad-spectrum antiviral agents as well as evasion mechanisms of the innate immune system against picornavirus 3Cpro through continued research of picornavirus 3Cpro.
