Genotype of Rotavirus Vaccine Strain LLR in China is G10P15.
- Author:
Dandi LI
;
Ziqian XU
;
Guangcheng XIE
;
Hong WANG
;
Qing ZHANG
;
Xiaoman SUN
;
Nijun GUO
;
Lili PANG
;
Zhaojun DUAN
- Publication Type:Journal Article
- MeSH:
China;
Genotype;
Humans;
Molecular Sequence Data;
Phylogeny;
Rotavirus;
chemistry;
classification;
genetics;
isolation & purification;
Rotavirus Infections;
virology;
Rotavirus Vaccines;
chemistry;
classification;
genetics;
isolation & purification;
Sequence Homology, Amino Acid;
Viral Proteins;
chemistry;
genetics
- From:
Chinese Journal of Virology
2015;31(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Rotavirus is the leading causal agent of severe acute gastroenteritis in children aged <5 years. A specific pharmacologic agent for the treatment of rotavirus-infected children is lacking. In China, only the Luo Tewei oral vaccine (Lanzhou Institute of Biological Products, Shanghai, China), which is produced from Lanzhou lamb rotavirus vaccine (LLR), is available. Studies have hypothesized that the genotype of LLR is G10P[12], To identify the genotype of LLR by reverse transcription-polymerase chain reaction, we showed that the VP7 and VP4 genotypes of LLR were G10 and P[15], respectively, based on sequencing, alignment and phylogenetic analyses. In conclusion, we identified the genotype of rotavirus strain LLR to be G10P[15].
