Advances in Understanding Carcinogenetic Mechanisms of the Human Papillomavirus and Vaccines Based on Virus-like Particles.
- Author:
Zhihong ZHAO
;
Lili WANG
;
Bo MA
- Publication Type:Journal Article
- MeSH:
Animals;
Carcinogenesis;
Female;
Humans;
Papillomaviridae;
genetics;
immunology;
metabolism;
Papillomavirus Infections;
pathology;
prevention & control;
virology;
Papillomavirus Vaccines;
genetics;
immunology;
Uterine Cervical Neoplasms;
pathology;
prevention & control;
virology;
Viral Proteins;
genetics;
immunology;
metabolism
- From:
Chinese Journal of Virology
2015;31(2):180-186
- CountryChina
- Language:Chinese
-
Abstract:
Prevention of infection by the human papillomavirus (HPV) has become a hot research topic since the relationship between the HPV and cervical cancer was confirmed. Persistent infection with HPV and early expression of proteins has an important role in the pathogenesis of cervical cancer. Vaccines that protect against four high-risk types of HPV (-6, -11, -16, -18) have been used worldwide. A bivalent vaccine (HPV-16 and -18) developed by Walvax is in clinical trials. This study reviews progress in ascertainment of the structure and function of the HPV genome, the molecular mechanism of carcinogenesis, and vaccines based on virus-like particles.
