Therapeutic effect and toxicity of compound vincristine liposome on breast cancer in nude mice.
- Author:
Tong CHEN
1
;
Shixiang HOU
;
Yongyan WANG
;
Wensheng ZHANG
;
Hui LIAO
Author Information
1. Institute of Resources Medicine and Chinese Medical Resources, Beijing Normal University, Beijing 100875, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Carriers;
Drug Synergism;
Female;
Liposomes;
administration & dosage;
Mammary Neoplasms, Experimental;
drug therapy;
pathology;
Mice;
Mice, Inbred BALB C;
Mice, Nude;
Mitoxantrone;
administration & dosage;
adverse effects;
Neoplasm Transplantation;
Random Allocation;
Vincristine;
administration & dosage;
adverse effects
- From:
Journal of Biomedical Engineering
2009;26(1):127-143
- CountryChina
- Language:Chinese
-
Abstract:
This study was intended to assess the therapeutic effect and toxicity of Compound vincristine liposome on breast cancer in nude mice. The mammary cancer models of BALB/c nude mice were set up using MCF-7 cells, and were divided into seven groups: MTO-VCR-LP, MTO-VCR-Soln, VCR-LP, VCR-Soln, MTO-LP, MTO-Soln and 0.9% NaCl. After the first treatment in the same day of transplantation, different treatments were given respectively. According to the design, the BLAB/c nude mice were given the therapy, the weight of nude mice and tumor volume were measured, and the tumor growth inhibitory rate was calculated. Bone marrow smears and extravasation injury were observed. The tumor growth inhibitory rates were higher in MTO-VCR-LP and MTO-VCR-Soln groups than in other groups. MTO-VCR-Soln, VCR-Soln and MTO-Soln led to severe local extravasation injury. MTO-VCR-Soln cause serious bone marrow inhibition of nude mice. The average weight of nude mice in the three liposome groups was higher than that in the three solution groups. So the use of liposome as the carriers of the two anticancer drugs could improve the cure rate of cancer and decrease the side-effects. This work, which not only expanded the research field of liposome but also brought in new ideas and new methods to treat cancer. Furthermore, the findings in this research may have the potential for use in clinical practice.
