The box-dimension-based localization of neuronal structures in pallidotomy for treatment of Parkinson's disease.
- Author:
Xinwen LIU
1
;
Zhiyu QIAN
;
Huinan WANG
;
Tianming YANG
;
Kunshan LI
Author Information
1. Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. lxwlq2003@163.com
- Publication Type:Journal Article
- MeSH:
Electrophysiology;
Globus Pallidus;
physiopathology;
surgery;
Humans;
Microelectrodes;
Neurons;
physiology;
Pallidotomy;
methods;
Parkinson Disease;
physiopathology;
surgery;
Stereotaxic Techniques;
Surgery, Computer-Assisted;
methods
- From:
Journal of Biomedical Engineering
2009;26(1):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the intraoperative location of microelectrode position in the globus pallidus is subjective and qualitative; it only depends on the experience of doctors during pallidotomy for the treatment of Parkinson's disease. The fractal characteristic of neuronal discharge signals is analyzed for target localization; the factor of box dimension is extracted from the microelectrode recordings for identifying the neuronal structures at the depth of microelectrode. New objective and quantitative targeting technique is presented by processing clinical microelelctrode recordings of Parkinson's disease. Through the validation of clinical data and the critical appraisal by experts, the targeting technique can be used for improving the accuracy of localization in neurosurgery.
