Design of transdermal ultrasonophoresis equipment.
- Author:
Liangcheng LI
1
;
Yongshun ZHANG
;
Zhonghong LI
Author Information
1. Staff Room of Medical Image, Bethune Military Medical College, Shijiazhuang 050081, China. liliangcheng@126.com
- Publication Type:Journal Article
- MeSH:
Administration, Cutaneous;
Drug Delivery Systems;
instrumentation;
methods;
Equipment Design;
Humans;
Pharmaceutical Preparations;
administration & dosage;
Skin Absorption;
radiation effects;
Ultrasonics
- From:
Journal of Biomedical Engineering
2009;26(1):184-186
- CountryChina
- Language:Chinese
-
Abstract:
The recent fast development in biotechnology has resulted in a large number of therapeutic biologicals coming in the foreground for clinical application. Transdermal drug delivery (TDD) is designed for patching the drug on the skin, and then the drug molecules permeate through the skin into the subcutaneous capillary vessels. However,very few drugs can be administered transdermally at the therapeutic levels to pass through the barrier of stratum corneum. Several physical and chemical methods are applied to improve the permeability of skin. Research result shows that the low-frequency ultrasonic technique can extraordinarily increase the rate of permeation. As a result, it is becoming one of the potential methods that serve as the substitutes for traditional methods. In this paper is presented a type of equipment based on MSP430. The principle of design, the structure of hardware, and the applied function in this area are described.
