Negative regulation of cells proliferation by Gax gene and its mechanisms.
- Author:
Shijin XIA
1
;
Xiantao TAI
;
Guisheng QIAN
Author Information
1. Laboratory of Cellular and Molecular Biology, Institute of Integrated Traditional Chinese and Western Medicine, Affiliated Huashan Hospital, Fudan University, Shanghai 200040, China.
- Publication Type:Journal Article
- MeSH:
Cell Proliferation;
drug effects;
Cells, Cultured;
Endothelial Cells;
cytology;
Gene Expression;
Homeodomain Proteins;
genetics;
metabolism;
Humans;
Muscle, Smooth, Vascular;
cytology
- From:
Journal of Biomedical Engineering
2009;26(1):206-210
- CountryChina
- Language:Chinese
-
Abstract:
Gax gene is a newly found negative transcriptional regulator of cells proliferation. This paper introduces the detection and structural features of Gax, details the inhibitory effect of Gax on the proliferation of vascular smooth muscle cells, vascular endothelial cells and cancer cells, and explains the putative mechanisms therein involved. The potential for providing therapeutic insights into human diseases by modulating Gax activity is prospected.
