Protective effects of Hongbeiyegen against immunological liver injury in mice.
- Author:
Yu-hong SONG
1
;
Qiang LIU
;
Yu-yao CHEN
;
Zhi-ping LÜ
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; pharmacology; therapeutic use; Euphorbiaceae; chemistry; Female; Interleukin-1beta; metabolism; Lipopolysaccharides; Liver; drug effects; metabolism; pathology; Liver Diseases; immunology; prevention & control; Male; Mice; Mice, Inbred Strains; Mycobacterium bovis; Nitric Oxide; blood; Phytotherapy; Plant Roots; chemistry; Treatment Outcome; Tumor Necrosis Factor-alpha; metabolism
- From: Journal of Southern Medical University 2008;28(3):494-496
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of Hongbeiyegen (HBYG) against immunological liver injury induced by bacille Calmette-Guerin (BCG) and lipopolysaccharide (LPS).
METHODSImmunological liver injury was induced in rats by BCG and LPS injected via the tail vein. The liver index, thymus index and spleen index were calculated and the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and nitric oxide (NO) and liver homogenate contents of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were determined.
RESULTSHBYG significantly improved the liver index, thymus index and spleen index, and reduced the serum levels of ALT, AST and NO, and as the liver homogenate contents of TNF-alpha and IL-1beta.
CONCLUSIONHBYG offers obvious protective effects against immunological injury liver in mice.
