Establishment of a rat model of diabetic erectile dysfunction.
- Author:
Yi CHENG
1
;
An-yang WEI
;
Yu-gang LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apomorphine; Diabetes Mellitus, Experimental; chemically induced; complications; Disease Models, Animal; Erectile Dysfunction; etiology; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin
- From: Journal of Southern Medical University 2008;28(4):564-566
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a rat model of diabetic erectile dysfunction (ED) with streptozotocin (STZ) injection.
METHODSThirty male rats were randomized equally into 5 groups (control group and STZ 40 mg/kg, 60 mg/kg, 80 mg/kg, and 100 mg/kg groups). All the rats were examined at 4 days and 1, 2, and 3 weeks after STZ injection for fasting blood glucose, erectile frequency induced by apomorpHine (APO) and body weight changes.
RESULTSSignificant difference occurred in the fasting food glucose among the groups at different time points (P=0.001), and also in APO-induced erectile frequency, fasting blood glucose and body weight between the groups with STZ injection at different doses (P<0.001, P=0.045 and P<0.001, respectively). No significant difference was found in induced erectile frequency and body weight between different time points (P=0.306 and P=0.628).
CONCLUSIONThe optimal dose of STZ for establishing diabetic ED model is 60 mg/kg, and two weeks after the injection can be the optimal time for evaluating model establishment by means of APO-induced penis erection.
