Peripheral natural killer cell counting and its clinical significance blood in patients with bronchial asthma.
- Author:
Fang LIU
1
;
Ya-ling LUO
;
Yue-xian WU
;
Qing-yu KONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asthma; blood; immunology; Cell Count; methods; Female; Flow Cytometry; Humans; Killer Cells, Natural; cytology; immunology; Male; Middle Aged
- From: Journal of Southern Medical University 2008;28(5):780-782
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in natural killer (NK) cell count in the peripheral blood of asthmatic patients.
METHODSThe number of NK cells in the peripheral blood was determined with flow cytometry in 63 asthmatic patients with acute episodes, 65 patients with stable asthma and 62 healthy nonatopic subjects.
RESULTSA significant decrease in NK cell number was noted in asthmatic patients during acute exacerbation [(13.9-/+9.4) %] in comparison with patients with stable asthma [(22.5-/+12.3) %] and healthy subjects [(19.6-/+10.1)%] (P<0.05), and the NK cell number showed no significant difference between the latter two groups (P>0.05).
CONCLUSIONNK cell number is reduced in acute exacerbation of asthma, suggesting its important role in the asthmatic process.
