RANTES expression in venous ulceration of lower limbs.
- Author:
Liu-hua CHEN
1
;
Cai-sheng YE
;
Heng-hui YIN
;
Jie-lian YE
;
Shen-ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chemokine CCL5; biosynthesis; blood; genetics; Female; Humans; Male; Middle Aged; RNA, Messenger; biosynthesis; genetics; Reverse Transcriptase Polymerase Chain Reaction; Varicose Ulcer; blood; etiology; Venous Insufficiency; blood; complications; Young Adult
- From: Journal of Southern Medical University 2008;28(5):861-862
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of RANTES in venous ulceration.
METHODSFrom patients with lower limb venous ulceration, patients with non-ulcerous venous insufficiency, and healthy individuals, peripheral blood was collected from the lower limb veins for measurement of RANTES mRNA using RT-PCR.
RESULTSIn the ulceration group, the expression of RANTES mRNA was significantly increased as compared with the other two groups (P<0.01). RANTES mRNA expression was also significant higher in the non-ulcerous group than the control group (P<0.01).
CONCLUSIONHigh expression of RANTES mRNA may be one of the important mechanisms of venous ulceration.
