Effects of interferon on hepatic intercellular adhesion molecule-1 expression in patients with chronic hepatitis B.
- Author:
Rui-dan ZHENG
1
;
Cheng-run XU
;
Min-feng ZHANG
;
Jia-rong MENG
;
Ri-chun RAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; DNA, Viral; blood; Female; Hepatitis B virus; drug effects; genetics; Hepatitis B, Chronic; blood; drug therapy; virology; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; biosynthesis; Interferon-alpha; therapeutic use; Liver; drug effects; metabolism; virology; Male; Middle Aged; Polymerase Chain Reaction; methods; Viral Load; Young Adult
- From: Journal of Southern Medical University 2008;28(5):878-879
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of interferon -alpha1b (IFN-alpha1b) on hepatic intercellular adhesion molecule-1 (ICAM-1) expression and serum HBV DNA in patients with chronic hepatitis B.
METHODSBefore and 6 months after IFN-alpha1b treatment, liver biopsy was performed in patients with chronic hepatitis B to detect the expression of ICAM-1 in the liver tissues using immunohistochemistry. Serum HBV load was detected with real-time fluorescence polymerase chain reaction.
RESULTCAM-1 expression in the liver tissue was significantly down-regulated after IFN treatment in patients with severe and moderate chronic hepatitis B (P<0.05). No significant variation was noted in the expression of ICAM-1 in the livers of patients with mild chronic hepatitis B after the treatment (P>0.05). In the patients weakly positive for ICAM-1 expression (+), serum HBV DNA varied scarcely after the treatment (P>0.05), while in the patients with strong ICAM-1 positivity (++, +++, or ++++), significant variation of serum HBV DNA occurred after the treatment (P<0.05 or P<0.01).
CONCLUSIONThe therapeutic effect of IFN-alpha1b is associated with the expression of ICAM-1 in the hepatocytes, and its expression might enhance the effects of IFN on HBV DNA in patients with chronic hepatitis B.
