Polymorphisms within the interferon-Gamma receptor associated with systemic lupus erythematosus.
- Author:
Xu YAO
1
;
Yu-mei LI
;
Zi-jia HU
;
Wen-zhong LI
;
Zhi-qiang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Base Sequence; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Lupus Erythematosus, Systemic; genetics; Male; Middle Aged; Polymorphism, Genetic; genetics; Polymorphism, Single-Stranded Conformational; Receptors, Interferon; genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2005;22(3):320-323
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between polymorphisms within the interferon-Gamma receptor gene(IFN-GammaR) and systemic lupus erythematosus (SLE) in Chinese people.
METHODSThe IFN-GammaR genotypes of 94 SLE patients and 80 healthy subjects were examined by the reverse transcription-polymerase chain reaction (RT-PCR)-single-strand conformation polymorphism (SSCP) method, RT-PCR-restriction fragment length polymorphism (RFLP) method and DNA sequencing.
RESULTSThere was no statistically significant difference in the IFN-GammaR genotype frequencies between the two groups. The IFN-Gamma R2 Arg64/Arg64 genotype decreased the risk of SLE (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047). The decreased risk of the development of SLE was detected in the individuals who had the combination of IFN-GammaR2 Arg64/Arg64 genotype and IFN-GammaR1 Val14/Val14 genotype (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047).
CONCLUSIONThe IFN-GammaR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-Gamma R2 Arg64/Arg64 genotype and IFN-Gamma R1 Val14/Val14 genotype does not, either.
