Study on the mechanism of oocyte aneuploidy by spectral karyotyping.
- Author:
Wen CHEN
1
;
Gui-jin ZHU
;
Liselotte METTLER
Author Information
- Publication Type:Journal Article
- MeSH: Aneuploidy; Female; Humans; Male; Oocytes; cytology; metabolism; Pregnancy; Reproducibility of Results; Spectral Karyotyping; methods
- From: Chinese Journal of Medical Genetics 2005;22(4):411-414
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish the method of detecting oocyte aneuploidy by spectral karyotyping (SKY).
METHODSThe unfertilized oocytes were fixed 1-2 days after oocyte retrieval. Spectral karyotyping was performed according to the protocol.
RESULTS64% of oocytes were normal, 36% of oocytes were aneuploidy, of which 22% were due to nondisjunction and 14% unbalanced predivision.
CONCLUSIONSKY is an effective method for detecting oocyte aneuploidy. Both nondisjunction and unbalanced predivision are involved in oocyte aneuploidy formation.
