Association of two exonic genetic polymorphisms in the DNA repair gene XPC with risk of lung cancer in Chinese population.
- Author:
Zhi-bin HU
1
;
Yong-gang WANG
;
Hong-xia MA
;
Wen TAN
;
Ju-yin NIU
;
Dong-xin LIN
;
Hong-bing SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; DNA-Binding Proteins; genetics; Exons; genetics; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Lung Neoplasms; ethnology; genetics; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors
- From: Chinese Journal of Medical Genetics 2005;22(4):415-418
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between two exonic polymorphisms of DNA repair gene XPC and the susceptibility to lung cancer.
METHODSGenotypes were determined by the primer introduced restriction analysis-PCR(PIRA-PCR) and the PCR-restriction fragment length polymorphism(PCR-RFLP) approaches, respectively, in 320 histologically-confirmed lung cancer cases and 322 age and sex frequency-matched cancer-free controls.
RESULTSMultivariate logistic regression analysis revealed that individuals carrying at least one 499Val variant allele (Ala/Val + Val/Val genotypes) had a significantly increased risk for lung cancer (adjusted OR=1.54; 95%CI: 1.11-2.14), compared with the wild-type genotype (499Ala/Ala). Furthermore, individuals with both putative risk genotypes had a significantly higher risk (adjusted OR=2.55; 95%CI: 1.45-4.52), compared with those with both wild-genotypes. In addition, a potential super multiplicative gene-environment interaction between Ala499Val genotypes and smoking on lung cancer risk was unveiled. The odds ratios of lung cancer for individuals with both putative risk genotypes were 2.63 (95%CI=1.23-5.62) in nonsmokers and 7.36 (95%CI=3.19-17.0) in smokers, respectively.
CONCLUSIONThese findings support the hypothesis that these two XPC variants may contribute to the risk of developing lung cancer.
