HLA class I and II polymorphism and haplotypes in Guangdong Han population.
- Author:
Hong-jing MA
1
;
Xiao-lin YIN
;
Kun-yuan GUO
;
Lu-lu XIAO
;
Xin YE
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; Gene Frequency; HLA Antigens; genetics; HLA-A Antigens; genetics; HLA-B Antigens; genetics; HLA-C Antigens; genetics; HLA-DR Antigens; genetics; Haplotypes; genetics; Humans; Linkage Disequilibrium; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2005;22(4):467-469
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the polymorphism and haplotypes of HLA class I and II in Guangdong Han population and detect the HLA-A, B, Cw and DRB1 allele frequencies.
METHODSAn auto semi-quantitative PCR-sequence speacific oligonucleotide probe(PCR-SSOP) method was adopted in exploring the HLA-A, B, Cw and DRB1 genotypes of the samples from 160 bone marrow donors.
RESULTSTwelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles were obtained. A total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes were found.
CONCLUSIONHLA class I and II alleles in Guangdong Han population have plenty of polymorphisms. The haplotype distribution possesses territory characteristic.