Distribution of genotype and allele frequencies of dopamine D4 receptor gene 48 bp variable number tandem repeat polymorphism in Chinese Han population in Hunan.
- Author:
Ai-ling ZHAO
1
;
Jing-ping ZHAO
;
Yu-hu ZHANG
;
Bei-sha TANG
;
Zhe-ning LIU
;
Jin-dong CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genotype; Humans; Male; Minisatellite Repeats; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Dopamine D4; genetics
- From: Chinese Journal of Medical Genetics 2005;22(4):470-472
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of genotype and allele frequencies of the dopamine D4 receptor(DRD4) gene exon 3 48 bp variable number of tandem repeats polymorphism in Hunan Han population.
METHODSThe genotype and alleles of 304 healthy persons were examined with polymerase chain reaction, denaturing polyacrylamide gel electrophoresis and silver staining.
RESULTSSeven alleles and twelve genotypes were found. The most common allele was allele 5 with a frequency of 70.6%. There was statistically significant difference in allele distribution between the Hunan Han population and the Han population of other regions such as Shanghai, Beijing and Sichuan in China (P< 0.05). Different allele frequency distributions were observed when compared to other ethnic populations such as Japanese, American, Mexican, and Italian (P< 0.05).
CONCLUSIONThe distributions of allele of DRD4 gene exhibit regional and ethnic heterogeneity.
