Effect of polymorphism of uncoupling protein 3 gene -55 (C>T) on the resting energy expenditure, total body fat and regional body fat in Chinese.
- Author:
Qi-chen FANG
1
;
Wei-ping JIA
;
Ming YANG
;
Yu-qian BAO
;
Lei CHEN
;
Rong ZHANG
;
Kun-san XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adipose Tissue; metabolism; Asian Continental Ancestry Group; genetics; China; Energy Metabolism; physiology; Female; Humans; Ion Channels; genetics; physiology; Male; Middle Aged; Mitochondrial Proteins; genetics; physiology; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Uncoupling Protein 3
- From: Chinese Journal of Medical Genetics 2005;22(5):485-488
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the relationship of the C to T variant at the -55 site of the promoter region of uncoupling protein 3 gene (UCP3) with the resting energy expenditure and the parameters of body fat in Chinese population.
METHODSThree hundred Chinese (91 normal weight subjects, 209 overweight/obesity subjects) were genotyped for the UCP3 gene -55(C>T) by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Resting energy expenditure (REE), fat mass (FM), fat free mass (FFM) and the parameters for regional adipose tissue distribution were measured.
RESULTSGenotype frequencies of UCP3 gene -55(C>T) were not associated with obesity and different types of obesity. The REE level in normal weight subjects with TT homozygotes was higher than that in those with CT heterozygotes and CC homozygotes (P=0.0200). Similar tendency was also observed in overweight/obesity subjects. The FM/FFM exhibited significant difference between the overweight/obesity subjects with a TT genotype and those with a CT or CC genotype (P=0.0096).
CONCLUSIONThe level of difference in REE caused by the polymorphism of promoter region of UCP3 -55(C>T) may play a role in energy metabolism in Chinese.
