Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene.
- Author:
Wei-hua YUE
1
;
Po-zi LIU
;
Wei HAO
;
Xiang-hui ZHANG
;
Xiao-ping WANG
;
Ji-shui ZHANG
;
Xu-hui ZHOU
;
Yong-biao XIE
;
Ming NI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Middle Aged; Minisatellite Repeats; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; genetics; Serotonin Plasma Membrane Transport Proteins; genetics; Sleep Apnea Syndromes; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2005;22(5):533-536
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS).
METHODSFor two polymorphisms of 5-HTT target DNA gene was amplified using polymerase chain reaction (PCR) and 6% non-denaturing polyacrylamide gels electrophoresis. The frequencies of the different forms of the genotypes and alleles of 5-HTT gene were analyzed in 104 patients with SAS and 150 healthy controls.
RESULTSThe frequencies of the S or L alleles and the S/S, S/L or L/L genotypes in promoter region of 5-HTT gene in SAS group were not significantly different to those in healthy controls (P > 0.05). However, the frequencies of 10/10, 12/10 genotypes of 5-HTT-VNTR in SAS patients were significantly higher than those in healthy control subjects (P < 0.05). Moreover, the frequency of the allele 10 of 5-HTT-VNTR in SAS patients was significantly higher than that in healthy controls (P<0.01).
CONCLUSIONThe allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of SAS.
