Correlation between fibrinogen polymorphisms and the type of cerebral infarction.
- Author:
Shu-juan WANG
1
;
Xiao-dong YUAN
;
Jie GAO
;
Huan-zhen PEI
;
Hong-fen LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cerebral Infarction; blood; genetics; Female; Fibrinogen; genetics; metabolism; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2005;22(5):572-574
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction.
METHODSGene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined.
RESULTSThe Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients.
CONCLUSIONFgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.
