No association of -1438G/A polymorphism in promoter region of 5-HT2A receptor gene with antipsychotic agent-induced weight gain.
- Author:
Xiao-dong MOU
1
;
Zhi-jun ZHANG
;
Zhi-jian YAO
;
Wen LIU
;
Xiang-rong ZHANG
;
Jia-bo SHI
;
Jing SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antipsychotic Agents; therapeutic use; Chlorpromazine; therapeutic use; Female; Gene Frequency; Genotype; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; genetics; Receptor, Serotonin, 5-HT2A; genetics; Risperidone; therapeutic use; Schizophrenia; drug therapy; genetics; physiopathology; Weight Gain; drug effects; genetics
- From: Chinese Journal of Medical Genetics 2005;22(5):575-576
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether the -1438G/A polymorphism in the promoter region of 5-HTR2A gene associates with the weight gain following antipsychotic agents (APS) acute treatment in schizophrenic patients.
METHODSEighty-four Chinese Han patients with schizophrenia at the first onset were recruited from among 70 nuclear families. The polymorphism of 5-HTR2A gene was determined with PCR-RFLP technique. Body weight was measured in the patients on admission after 10 weeks of treatment with risperidone or chlorpromazine.
RESULTSThere were no statistically significant differences in the distribution frequencies of genotype (chi2: 0.172, v1, P > 0.05) and allele (chi2: 0.121, v1, P > 0.05) of -1438G/A polymorphism of 5-HTR2A gene between subgroups (weight gain >or= 7% or < 7%). Likewise, there was no significant difference in weight gain between genotype groups. By means of transmission disequilibrium test and quantitative transmission disequilibrium test, no significant association between the -1438G/A polymorphism of 5-HTR2A gene and weight gain was observed.
CONCLUSION5-HTR2A gene -1438G/A polymorphism was probably not associated with APS-induced weight gain in Chinese Han patients with schizophrenia in this study.
