Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province.
- Author:
Tao LAN
1
;
De-mei ZHANG
;
Gui-qin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; HLA-A Antigens; genetics; HLA-B Antigens; genetics; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Young Adult
- From: Chinese Journal of Medical Genetics 2005;22(5):583-584
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphism of HLA-A, -B, -DRB1 genes in Han population in Shanxi of China.
METHODSPolymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to identify the polymorphism of HLA-A, -B, -DRB1 genes of 7440 healthy and unrelated individuals of Han population in Shanxi, and the gene frequency distribution of HLA-A, -B, -DRB1 genes in population was compared with the results from other populations.
RESULTSEighteen HLA-A, forty HLA-B and thirteen HLA-DRB1 alleles were found. The frequencies of A*02, A*24, A*11, A*01, A*03, B*13, B*51, B*15, B*40, B*35, DRB1*15, DR*09, DR*12, DR*04, DR*07 alleles in Hans of Shanxi were significantly higher and displayed distinctive distribution profiles when compared with those of Caucasian and Afro-American.
CONCLUSIONThe HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics.
