Association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan.
- Author:
Hong-ying YANG
1
;
Chun-feng REN
;
Li XUE
;
Hui-yun YUAN
;
Mian XU
;
Wen-lin TAI
;
Jiang LI
;
Yu YANG
;
Juan DU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; China; Diabetes Mellitus, Type 2; genetics; Female; Genetic Predisposition to Disease; genetics; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2005;22(6):702-704
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yi nationality of Yunnan.
METHODSPolymerase chain reaction with sequence-specific primers (PCR-SSP) genotyping method was conducted in 58 ethnic Yi patients with type 2 diabetes mellitus and 82 ethnically matched controls from Chuxiong of Yunnan. Then a study was made on the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes mellitus.
RESULTSThe frequency of HLA-DQA1*0301 allele in the patients with type 2 diabetes mellitus was significantly higher than that in the healthy controls (P=0.002, RR=3.097), and the frequency of HLA-DQA1*0601 in the patients was significantly lower (P=0.025, RR=0.429).
CONCLUSIONIn Yi nationality of Yunnan, HLA-DQA1*0301 allele may be a susceptible gene and the HLA-DQA1*0601 allele may protect individuals from the risk of diabetes mellitus.
