Association of FGF23 gene polymorphism with Kawasaki disease and coronary artery lesions.
- Author:
Ya-Nan GENG
1
;
Hong-Yan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Coronary Artery Disease; etiology; genetics; Female; Fibroblast Growth Factors; genetics; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; etiology; genetics; Polymerase Chain Reaction; Polymorphism, Genetic
- From: Chinese Journal of Contemporary Pediatrics 2015;17(10):1107-1111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of polymorphism of c.212-37insC (rs3832879) in intron 1 of fibroblast growth factor 23 (FGF23) gene and its association with Kawasaki disease (KD) and coronary artery lesions (CAL).
METHODSForty children with KD were enrolled in this study, among whom 16 children had concurrent CAL. Twenty-six age-matched healthy children were enrolled as controls. PCR and gene sequencing were applied to explore the distribution of polymorphism of c.212-37insC (rs3832879) in FGF23 gene in KD patients and controls.
RESULTSAmong 40 children with KD, 14 (35%) carried the polymorphism of c.212-37insC (rs3832879) in FGF23 gene; among 26 controls, 6 (23%) carried such polymorphism. There was no significant difference in genotype distribution at this locus between the two groups (P=0.30). Among 16 children with CAL, 9 (56%) carried the polymorphism at this locus; among 24 children without CAL, 5 (21%) carried such polymorphism. As for the comparison of two subgroups with and without CAL, the difference in genotype distribution at this locus had statistical significance (P=0.02, OR=4.89, 95% CI: 1.21-19.71).
CONCLUSIONSThe polymorphism of c.212-37insC (rs3832879) in FGF23 gene may not be associated with the pathogenesis of childhood KD, but it may be associated with the development of CAL in children with KD.
