Association of TIAM1 gene polymorphisms with Kawasaki disease and its clinical characteristics.
- Author:
Xian WANG
1
;
Tian-Jiao ZHU
;
Xiong-Fei ZHOU
;
Zhi-Ting WAN
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Guanine Nucleotide Exchange Factors; genetics; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; genetics; Polymorphism, Single Nucleotide; T-Lymphoma Invasion and Metastasis-inducing Protein 1
- From: Chinese Journal of Contemporary Pediatrics 2015;17(11):1217-1220
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children.
METHODSA case-control study was performed in this study. One hundred and eighty-eight children with KD and 197 normal children served as controls were enrolled. The genotypes of two SNPs rs22833188 and rs2833195 in TIAM1 gene were detected using PCR-RFLP.
RESULTSThere were no significant differences in the genotype (AA, AG and GG) and allele frequencies of SNP rs2833188 between the KD and control groups. Significant differences in the genotype (CC, GC and GG) frequency of SNP rs2833195 were noted between the KD and control groups (P=0.017). The frequency of C allele in the KD group was higher than in the control group (P=0.015). The polymorphism of SNP rs2833188 was associated with the occurrence of rash (P=0.011), and the polymorphism of SNP rs2833195 was associated with the occurrence of conjunctival hyperemia (P=0.021).
CONCLUSIONSThe polymorphism of rs2833195 in TIAM1 gene is associated with the susceptibility to KD. The polymorphisms rs2833188 and rs2833195 in TIAM1 gene may be associated with some clinical characteristics in children with KD.
